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Biomarker Card

This biomarker card gives comprehensive information about each biomarker.
Detailed Information
Biomarker ID307
PMID18553995
Year2008
BiomarkerNucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Numatrin)
Biomarker BasisExpression Based
BiomoleculeProtein
SourceTissue
SubjectsHumans
RegulationUpregulated (Mean Ratio: 2.6 ±1.01)
Odds Ratio/Hazard Ratio/Relative RiskNA
Effect on PathwaysPathways Include:-Deposition of new CENP-A-containing nucleosomes at the centromere,HIF-1 transcriptional activity in hypoxia,BARD1 signaling events,Aurora B signaling, Interactions of HIV Vpr protein with host cellular proteins
ExperimentProstate cancer Vs Benign Prostatic Hyperplasia
Type of BiomarkerDiagnostic
Cohort20 patients were chosen for the study. 10 patients with Prostate Cancer and 10 patients with benign prostatic hyperplasia (BPH).
SenstivityNA
SpecificityNA
AUCNA
AccuracyNA
Level Of Significancep≤0.01
Method UsedIsobaric tag for relative and absolute quantitation (iTRAQ) , two-dimensional liquid chromatography-tandem mass spectrometry (2DLC-MS/MS)
ClinicalNo
RemarksMean ratio corresponds to the protein reporter ion intensity originating from PCa relative to BPH. Immunohistochemistry was performed on selected genes- PSMA, AMACR, and MUC18 to confirm iTRAQ results
Clinical Trial NumberNA
Degree Of ValidityNot validated on independent patient dataset
Technical NameNPM1