| Biomarker ID | 253 |
| PMID | 18343427 |
| Year | 2008 |
| Biomarker | AMACR (Alpha-methylacyl-coA racemase ) |
| Biomarker Basis | Expression Based |
| Biomolecule | Protein |
| Source | Tissue |
| Subjects | Humans |
| Regulation | Upregulated in PCa |
| Odds Ratio/Hazard Ratio/Relative Risk | OR: 5.182 (95% CI 1.739-15.437) |
| Effect on Pathways | Pathways include: Lipid and lipoprotein metabolism, T cell receptor regulation of apoptosis, Metabolism, Peroxisome, Beta-oxidation of pristanoyl-CoA |
| Experiment | High Grade Prostatic Intraepithelial Neoplasia Vs Prostate Cancer |
| Type of Biomarker | Diagnostic |
| Cohort | 62 patients diagnosed with HGPIN were included in th study. On a repeat biopsy, it was seen that 30 had Prostate Cancer and 32 did not have PCA. |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p=0.0044 |
| Method Used | Immunohistochemistry |
| Clinical | No |
| Remarks | Patients with AMACR positive HGPIN glands were more likely to have diagnosis of prostate cancer on subsequent biopsy than those with no AMACR positive HGPIN glands. |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | AMACR |