Biomarker ID | 251 |
PMID | 18336616 |
Year | 2008 |
Biomarker | PHLPP |
Biomarker Basis | Expression Based |
Biomolecule | mRNA |
Source | Tissue |
Subjects | Humans |
Regulation | Downregulated in Gleason Score 7-13 |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways Include:- Negative regulation of the PI3K/Akt network,NGF signaling via TRKA from the plasma membrane,Signaling by FGFR in disease, Signaling by the B cell receptor (BCR),PI3K events in ERBB2 signaling |
Experiment | Gleason Score 5-6 Vs Gleason Score 7-10 |
Type of Biomarker | Prognostic |
Cohort | 20 patients with Prostate Cancer were included in the study with age matched controls. |
Senstivity | NA |
Specificity | NA |
AUC | NA |
Accuracy | NA |
Level Of Significance | p<0.05 |
Method Used | qRT-PCR |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | PHLPP1 |