| Biomarker ID | 236 |
| PMID | 18047674 |
| Year | 2007 |
| Biomarker | Cytokeratin 5 (CK5) |
| Biomarker Basis | Expression Based |
| Biomolecule | mRNA |
| Source | Cell Lines |
| Subjects | Humans |
| Regulation | Upregulated in Dasatinib Sensitive Cell Lines (>3 fold) |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include: Delta Np63 pathway,Regular glucocorticoid receptor pathway,TSH regulation of gene expression |
| Experiment | Dasatinib Sensitive Vs Dasatinib Resistant Cell Lines |
| Type of Biomarker | Potential Predictive |
| Cohort | Dasatinib sensitive cell Lines (LNCaP, DU145, PC3, PWR1E, RWPE1, RWPE2, NB11, NB16, HPV10, HPV7,W99) and Dasatinib resistant cell lines (MDAPCa2b, 22Rv, VCaP, DUCaP, WPMY1) were analysed for the experiment. Data accesseble at: GSE9633 |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p<0.05 |
| Method Used | Microarray |
| Clinical | No |
| Remarks | Effects of Dasatinib was checked on 16 cell lines. 3 predictive biomarkers were discovered - AR, PSA, CK5. uPA was found to be a surrogate marker and EphA2 was found to be a sensitivity marker. |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on human patient cohort |
| Technical Name | KRT5 |