| Biomarker ID | 21 |
| PMID | 14654526 |
| Year | 2003 |
| Biomarker | F2R/PAR1 |
| Biomarker Basis | Expression Based |
| Biomolecule | mRNA |
| Source | Tissue |
| Subjects | Humans |
| Regulation | Downregulated in PCa(atleast 2 fold) |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include:-Acute myocardial infarction,Inhibition of platelet activation by aspirin,Prothrombin activation intrinsic pathway,Fibrinolysis pathway,Thrombin signaling through protease-activated receptors |
| Experiment | Normal Prostate vs Prostate Cancer |
| Type of Biomarker | Diagnostic |
| Cohort | 14 patients with prostate cancer and 7 normal prostates were included for analysis |
| Senstivity | NA |
| Specificity | NA |
| AUC | 0.878 |
| Accuracy | NA |
| Level Of Significance | p<0.05 |
| Method Used | qRT-PCR |
| Clinical | No |
| Remarks | Out of 291 genes, 46 genes showed differential expression, out of which a 4 gene panel was selected to differentiate b/w the patients who relapsed and those who did not. |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | F2R |