Biomarker ID | 202 |
PMID | 16618727 |
Year | 2006 |
Biomarker | ROBO1 (Roundabout, Axon Guidance Receptor, Homolog 1) [ROBO1 1419] |
Biomarker Basis | Expression Based |
Biomolecule | mRNA |
Source | Tissue |
Subjects | Humans |
Regulation | Downregulated |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways Include:- Abl role in Robo-Slit signaling,Activation of Rac,Signaling by Robo receptor,Post-translational regulation of adherens junction stability and disassembly, Netrin-1 signaling |
Experiment | Cancerous Tissue Vs Normal Tissue |
Type of Biomarker | Diagnostic |
Cohort | Two sets of Patients were included in the study. Set 1 included 10 cancerous, and 6 normal tissues. Set 2 included 12 cancerous and 10 normal tissues |
Senstivity | NA |
Specificity | NA |
AUC | NA |
Accuracy | NA |
Level Of Significance | 2.26E-07 |
Method Used | RT-PCR and qPCR |
Clinical | No |
Remarks | Brackets indicate ISOFORMS of the mRNA |
Clinical Trial Number | NA |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | ROBO1 |