Biomarker ID | 1955 |
PMID | 22589488 |
Year | 2012 |
Biomarker | Methylation status of HIF3A |
Biomarker Basis | Methylation Based |
Biomolecule | Methylation |
Source | Tissue |
Subjects | Humans |
Regulation | Differentially Methylated between PCa and Normal |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | NA |
Experiment | Tumor Vs Normal Tissues |
Type of Biomarker | Diagnostic |
Cohort | 198 Prostate Cancer and 40 matched normal tissues; Validation: 20 cancer and 20 Normal |
Senstivity | Training: 95.6 (91.1–98.2) ; Validation 90.0 (68.3-98.77) |
Specificity | Training:100 (89.7–100); validation: 100 (83.1–100) |
AUC | Training: 0.989; Validation: 0.932 |
Accuracy | NA |
Level Of Significance | <0.0001 |
Method Used | Pyrosequencing |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Validated on independent patient dataset |
Technical Name | HIF3A |