Biomarker ID | 1931 |
PMID | 25786615 |
Year | 2013 |
Biomarker | let-7a* |
Biomarker Basis | Expression Based |
Biomolecule | miRNA |
Source | Serum |
Subjects | Humans |
Regulation | Upregulated in PCa |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways Include(let-7a):- nucleoplasm; regulation of RNA metabolic process; DNA-binding transcription factor activity, RNA polymerase II-specific; regulation of nucleic acid-templated transcriptionregulation of transcription, DNA-templated |
Experiment | Disseminated PCa VS Localised PCa |
Type of Biomarker | Prognostic |
Cohort | Samples from 13 BPH patients (controls), 11 patients with localized PC (LPC), 9 patients with lymph node metastases (N1) or distant metastases (M1), and 11 patients with castration resistant PC (CRPC) were selected |
Senstivity | 50% |
Specificity | 100% |
AUC | 0.735 (95% CI: 0.562-0.908) |
Accuracy | NA |
Level Of Significance | p=0.012 |
Method Used | miRCURY LNA microRNA PCR |
Clinical | No |
Remarks | Specificity fixed at 100%, sensitivity is calculated accordingly; Disseminated Disease include N1, M1 and CRPC |
Clinical Trial Number | NA |
Degree Of Validity | Validated on independent patient dataset |
Technical Name | NA |