Biomarker ID | 1925 |
PMID | 25786615 |
Year | 2013 |
Biomarker | miR-551b |
Biomarker Basis | Expression Based |
Biomolecule | miRNA |
Source | Serum |
Subjects | Humans |
Regulation | Upregulated in PCa [mean PC/mean]: (2.30 fold) |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathway include: macromolecule metabolic process; regulation of metabolic process; anatomical structure morphogenesis; positive regulation of transcription, DNA-templated; regulation of gene expression |
Experiment | Prostate Cancer Vs Benign Prostatic hyperplasia |
Type of Biomarker | Diagnostic |
Cohort | Samples from 13 BPH patients (controls), 11 patients with localized PC (LPC), 9 patients with lymph node metastases (N1) or distant metastases (M1), and 11 patients with castration resistant PC (CRPC) were selected |
Senstivity | 35% |
Specificity | 100% |
AUC | 0.682 (95% CI: 0.575-0.790) |
Accuracy | NA |
Level Of Significance | p=0.017 |
Method Used | miRCURY LNA microRNA PCR |
Clinical | No |
Remarks | Specificity fixed at 100%, sensitivity is calculated accordingly |
Clinical Trial Number | NA |
Degree Of Validity | Validated on independent patient dataset |
Technical Name | NA |