| Biomarker ID | 1919 |
| PMID | 25786615 |
| Year | 2013 |
| Biomarker | miR-17* |
| Biomarker Basis | Expression Based |
| Biomolecule | miRNA |
| Source | Serum |
| Subjects | Humans |
| Regulation | Upregulated in Metastatic PCa: [HSP27 (2.01 fold); prohibitin (1.88 fold); GSTP1 (1.18 fold); fibrinogen β chain (2.68 fold); ALDH6A1 (2.89 fold);Downregulated in Metastatic PCa [A1AT (0.84 fold) ; HSP60 (0.19 fold);] |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathway include: MicroRNAs in cancer; DNA Damage Response; Parkinsons Disease Pathway |
| Experiment | Prostate Cancer Vs Benign Prostatic hyperplasia |
| Type of Biomarker | Diagnostic |
| Cohort | Samples from 13 BPH patients (controls), 11 patients with localized PC (LPC), 9 patients with lymph node metastases (N1) or distant metastases (M1), and 11 patients with castration resistant PC (CRPC) were selected |
| Senstivity | 16% |
| Specificity | 100% |
| AUC | 0.655 (95% CI: 0.487-0.823) |
| Accuracy | NA |
| Level Of Significance | p=0.040 |
| Method Used | miRCURY LNA microRNA PCR |
| Clinical | No |
| Remarks | Specificity fixed at 100%, sensitivity is calculated accordingly |
| Clinical Trial Number | NA |
| Degree Of Validity | Validated on independent patient dataset |
| Technical Name | NA |