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Biomarker Card

This biomarker card gives comprehensive information about each biomarker.
Detailed Information
Biomarker ID1898
PMID30611450
Year2019
BiomarkerPTEN
Biomarker BasisExpression Based
BiomoleculeDNA (Copy Number variations)
SourceTissue
SubjectsHumans
RegulationUpregulated in Agressive PCa
Odds Ratio/Hazard Ratio/Relative RiskNA
Effect on PathwaysPathways include: Immune system, Disease, T cell receptor regulation of apoptosis, Adaptive immune system, TGF-beta regulation of extracellular matrix
ExperimentGleason Grade 4 in Gleason Score 7
Type of BiomarkerPrognostic
Cohort124 patients, were chosen GS6 (n=41), large volume GS6 (n=26), GS7 (n=28), and GS8 and higher (n=29).
SenstivityNA
SpecificityNA
AUC0.93 (95% CI: 0.86-0.99)
AccuracyNA
Level Of Significancep<0.01
Method Usedfluorescence in situ hybridization (FISH)
ClinicalNo
RemarksNA
Clinical Trial NumberNA
Degree Of ValidityValidated on independent patient dataset
Technical NameNA