| Biomarker ID | 183 |
| PMID | 16618727 |
| Year | 2006 |
| Biomarker | ERBB3 (Erb-B2 Receptor Tyrosine Kinase 3) [ERBB3 1431] |
| Biomarker Basis | Expression Based |
| Biomolecule | mRNA |
| Source | Tissue |
| Subjects | Humans |
| Regulation | Upregulated |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include:-Neuroregulin receptor degredation protein-1 controls ErbB3 receptor recycling,Downregulation of ERBB2-ERBB3 signaling,GRB7 events in ERBB2 signaling,Alpha-6 beta-1 and alpha-6 beta-4 integrin signaling,ERBB2 role in signal transduction and oncology |
| Experiment | Cancerous Tissue Vs Normal Tissue |
| Type of Biomarker | Diagnostic |
| Cohort | Two sets of Patients were included in the study. Set 1 included 10 cancerous, and 6 normal tissues. Set 2 included 12 cancerous and 10 normal tissues |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | 0.001238 |
| Method Used | RT-PCR and qPCR |
| Clinical | No |
| Remarks | Brackets indicate ISOFORMS of the mRNA |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | ERBB3 |