| Biomarker ID | 1753 |
| PMID | 30818754 |
| Year | 2019 |
| Biomarker | 5-hmC (5-hydroxymethylcytosin)+ ERG negative |
| Biomarker Basis | Expression Based |
| Biomolecule | Protein |
| Source | Tissue |
| Subjects | Humans |
| Regulation | NA |
| Odds Ratio/Hazard Ratio/Relative Risk | HR: Univariate: 1.6 (95% CI: 1.1-2.4); Multivariate: 1.8 (95% CI: 1.2-2.7) |
| Effect on Pathways | NA |
| Experiment | Biochemical recurrence Vs No Biochemical Recurrence |
| Type of Biomarker | Prognostic |
| Cohort | 592 patients were selected in total. 246 had low 5hmc expression and 346 had high 5hmc expression |
| Senstivity | NA |
| Specificity | NA |
| AUC | 0.803 |
| Accuracy | NA |
| Level Of Significance | Univariate: p=0.01; Multivariate: p=0.003 |
| Method Used | Immunohistochemistry |
| Clinical | No |
| Remarks | The 10-year cumulative incidence of Biochemical Faliure was considered as Biochemicl Recurrence |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | NA |