| Biomarker ID | 1718 |
| PMID | 26238235 |
| Year | 2015 |
| Biomarker | TNKS2 (Tankyrase 2) [SNP: rs1539042 CG Vs GG] |
| Biomarker Basis | Mutation Based |
| Biomolecule | Mutation |
| Source | Blood |
| Subjects | Humans |
| Regulation | NA |
| Odds Ratio/Hazard Ratio/Relative Risk | HR:Univariate: 1.31 (95% CI: 1.02–2.60); Multivariate: 1.62 (95% CI: 1.05–2.41) |
| Effect on Pathways | Pathway include: Telomere Extension by Telomerase; Deubiquitination; HIV Life Cycle; Metabolism of proteins; Signaling by Wnt |
| Experiment | Biochemical recurrence Vs No Biochemical Recurrence |
| Type of Biomarker | Prognostic |
| Cohort | 1015 PCa cases and 1052 cancer-free controls were selected for this process. Out of those who experienced BCR, 41 had GG genotype, 47 had CG and 59 had CG or CC. Out of those who did not experience BCR, 155 had GG genotype, 134 had CG and 171 had CG or CC |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p=0.032 |
| Method Used | RT-PCR |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | NA |