| Biomarker ID | 158 |
| PMID | 15491717 |
| Year | 2004 |
| Biomarker | Caspase-3 |
| Biomarker Basis | Expression Based |
| Biomolecule | Protein |
| Source | Tissue |
| Subjects | Humans |
| Regulation | Downregulated (in JA compared to NJ) |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include:-Mitochondrial role in apoptotic signaling,Signaling by Hippo, Apoptotic signaling in response to DNA damage,Activation of DNA fragmentation factor,Cell cycle progression regulation by PLK3 |
| Experiment | Cancerous Tissue in Japanese American (JA) Vs Native Japanese (NJ) |
| Type of Biomarker | Diagnostic |
| Cohort | 52 Japanese Men were selected for this Study. 25 from Nagoya (Native Japanese), Japan and 25 from California, USA (Japanese American) |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p=0.01 |
| Method Used | Immunohistochemistry |
| Clinical | No |
| Remarks | Japenese American patients were believed to have high fat and low soy diet and Native American Men were believed to have High Soy and low Fat diet. The aim was to compare various biomarkers on the basis of thier diet. |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | CASP3 |