Biomarker ID | 1576 |
PMID | 25273821 |
Year | 2014 |
Biomarker | AKT1 (SNP: rs2494750) |
Biomarker Basis | Mutation Based |
Biomolecule | Mutation |
Source | Blood |
Subjects | Humans |
Regulation | NA |
Odds Ratio/Hazard Ratio/Relative Risk | HR; 0.45 (95% CI: 0.23-0.90) |
Effect on Pathways | Pathways include: CD40/CD40L signaling, PIK3C1/AKT pathway, PI3K/PLC/TRK pathway, PI3K/AKT activation, Inactivation of GSK3 by Akt causes accumulation of beta-catenin in alveolar macrophages |
Experiment | PCa-specific mortality Vs No PCa-specific mortality |
Type of Biomarker | Prognostic |
Cohort | 957 patients were taken for this study out of which 98 had PCa Specific death, 782 did not and 77 unknown reason deaths. |
Senstivity | NA |
Specificity | NA |
AUC | NA |
Accuracy | NA |
Level Of Significance | p=0.016 |
Method Used | MassARRAY iPLEX system |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Validated on independent patient dataset |
Technical Name | NA |