Biomarker ID | 1553 |
PMID | 25252191 |
Year | 2014 |
Biomarker | miR-221 |
Biomarker Basis | Expression Based |
Biomolecule | miRNA |
Source | Tissue |
Subjects | Humans |
Regulation | Downregulated in Recurrent Cases (Recurrent Median: 0.25; Control Median: 0.46) |
Odds Ratio/Hazard Ratio/Relative Risk | HR: 3.21 (95% CI: 1.21 - 8.53) |
Effect on Pathways | Pathway include: homophilic cell adhesion via plasma membrane adhesion molecules; transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; DNA binding; synapse |
Experiment | Recurrence Vs No Recurrence |
Type of Biomarker | Prognostic |
Cohort | 59 cases with Recurrence and 59 controls were used for the study |
Senstivity | NA |
Specificity | NA |
AUC | NA |
Accuracy | NA |
Level Of Significance | Regulation: p=0.0002; Univariate: p=0.02; Multivariate: p=0.05 |
Method Used | qRT-PCR |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | NA |