Biomarker ID | 1517 |
PMID | 25156059 |
Year | 2014 |
Biomarker | YWHAZ |
Biomarker Basis | Expression Based |
Biomolecule | Protein |
Source | Tissue |
Subjects | Humans |
Regulation | Increased expression in patients with Castration Resistant Prostate Cancer (CRPC) |
Odds Ratio/Hazard Ratio/Relative Risk | Univariate: HR: 4.13 (95% CI: 1.544 - 11.050); Multivariate: HR: 5.072 (95% CI: 1.529-16.827) |
Effect on Pathways | Pathways include: FoxO family signaling, Pathogenic Escherichia coli infection, LKB1 signaling events, Calcineurin-dependent NFAT signaling role in lymphocytes, PI3K/PLC/TRK pathway |
Experiment | Castration Resistant Prostate Cancer (CRPC) Vs No CRPC |
Type of Biomarker | Prognostic |
Cohort | 213 men who underwent radical prostatectomy were selected for analysis |
Senstivity | NA |
Specificity | NA |
AUC | NA |
Accuracy | NA |
Level Of Significance | Univariate: p=0.005; Multivariate: p = 0.008 |
Method Used | Immunohistochemistry |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | NA |