| Biomarker ID | 149 |
| PMID | 15491717 |
| Year | 2004 |
| Biomarker | PARP |
| Biomarker Basis | Expression Based |
| Biomolecule | Protein |
| Source | Tissue |
| Subjects | Humans |
| Regulation | Upregulated in PCa |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include:- HES/HEY pathway,Caspase cascade in apoptosis,Integrin-linked kinase signaling,Signaling by TGF-beta receptor complex, Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer |
| Experiment | Benign Vs Cancerous Tissue in Japanese American |
| Type of Biomarker | Diagnostic |
| Cohort | 50 Japanese Men were selected for this Study. 25 from Nagoya (Native Japanese), Japan and 25 from California, USA (Japanese American) |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p=0.01 |
| Method Used | Immunohistochemistry |
| Clinical | No |
| Remarks | Combination of 60 NMD were selected to differentiate between various groups. Cancer Vs Normal: Japanese American: ROC: 0.91,Sensitivity: 78%, Specificity: 87%, Accuracy: 83. Native japanese: ROC: 0.85, Sensitivity: 78%, Specificity: 78%, Accuracy: 78%. To distinguish PCa for Native Japanese Vs Japanese Americans: ROC: 0.88, Sensitivity: 83%, Specificity: 78%, Accuracy: 80% |
| Clinical Trial Number | NA |
| Degree Of Validity | Not validated on independent patient dataset |
| Technical Name | PARP1 |