Biomarker ID | 146 |
PMID | 15491717 |
Year | 2004 |
Biomarker | p27 |
Biomarker Basis | Expression Based |
Biomolecule | Protein |
Source | Tissue |
Subjects | Humans |
Regulation | Downregulated in PCa |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways Include:- Prostate cancer,Signaling by SCF-KIT, C-Myb transcription factor network,ERBB signaling pathway,Integrins in angiogenesis |
Experiment | Benign Vs Cancerous Tissue in Native Japanese |
Type of Biomarker | Diagnostic |
Cohort | 50 Japanese Men were selected for this Study. 25 from Nagoya (Native Japanese), Japan and 25 from California, USA (Japanese American) |
Senstivity | NA |
Specificity | NA |
AUC | NA |
Accuracy | NA |
Level Of Significance | p=0.01 |
Method Used | Immunohistochemistry |
Clinical | No |
Remarks | Combination of 60 NMD were selected to differentiate between various groups. Cancer Vs Normal: Japanese American: ROC: 0.91,Sensitivity: 78%, Specificity: 87%, Accuracy: 83. Native japanese: ROC: 0.85, Sensitivity: 78%, Specificity: 78%, Accuracy: 78%. To distinguish PCa for Native Japanese Vs Japanese Americans: ROC: 0.88, Sensitivity: 83%, Specificity: 78%, Accuracy: 80% |
Clinical Trial Number | NA |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | CDKN1B |