Biomarker ID | 1457 |
PMID | 25009296 |
Year | 2014 |
Biomarker | Brachyury |
Biomarker Basis | Expression Based |
Biomolecule | Protein |
Source | Tissue |
Subjects | Humans |
Regulation | Increases with increasing Gleason Score |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Brachyury are clustered in oncogenic-related pathways, namely cell motility, cell- cycle regulation, and cell metabolism |
Experiment | Gleason Score GS <7 Vs GS = 7 Vs GS >7 |
Type of Biomarker | Prognostic |
Cohort | The series included a total of 211 nonneoplastic tissue, 143 high-grade prostate intraepithelial neoplasia (PIN) lesions, and 409 primary prostate carcinomas. |
Senstivity | NA |
Specificity | NA |
AUC | NA |
Accuracy | NA |
Level Of Significance | p = 0.027 |
Method Used | Western Blot |
Clinical | No |
Remarks | Validated in 4 other data stats, found consistent results with 3 of them |
Clinical Trial Number | NA |
Degree Of Validity | Validated on independent patient dataset |
Technical Name | NA |