Biomarker ID | 1432 |
PMID | 24893170 |
Year | 2014 |
Biomarker | miR-519c-5p |
Biomarker Basis | Expression Based |
Biomolecule | miRNA |
Source | Tissue |
Subjects | Humans |
Regulation | Downregulated in Cases |
Odds Ratio/Hazard Ratio/Relative Risk | OR: 0.18 (95% CI: 0.07 - 0.49) p=0.001 |
Effect on Pathways | DNA binding; enzyme binding; hydrolase activity, acting on ester bonds; phosphoric ester hydrolase activity; transferase activity |
Experiment | Gleason Score ≥7 or Gleason Score =6 |
Type of Biomarker | Prognostic |
Cohort | The discovery cohort consisted of 48 patients with a post-surgical pathologic Gleason score of 7 or higher (case group) and 48 patients with a pathologic Gleason score of 6 (control group). |
Senstivity | NA |
Specificity | NA |
AUC | 0.79 (95% CI: 0.69-0.88) |
Accuracy | NA |
Level Of Significance | p<0.05 |
Method Used | qRT-PCR |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Validated on independent patient dataset |
Technical Name | NA |