Biomarker ID | 1413 |
PMID | 24740842 |
Year | 2014 |
Biomarker | CDON [SNP: rs3737336: CC vs. TT/TC] |
Biomarker Basis | Mutation Based |
Biomolecule | Mutation |
Source | Blood |
Subjects | Humans |
Regulation | NA |
Odds Ratio/Hazard Ratio/Relative Risk | HR: Univariate: Cohort 1+2: [1.54 (95% CI: 1.1.07–2.20)]HR: Multivariate: Cohort 1: [1.95 (95% CI: 1.09–3.51)]; Cohort 1+2: [1.72 (95% CI: 1.16–2.55)] |
Effect on Pathways | Pathways include: Signaling events mediated by the hedgehog family, CDO in myogenesis, Hedgehog signaling pathway, Developmental biology |
Experiment | Biochemical recurrence Vs No Biochemical Recurrence |
Type of Biomarker | Prognostic |
Cohort | two independent cohorts composed of 320 Asian and 526 Caucasian men with pathologically organ-confined prostate cancer were selected |
Senstivity | NA |
Specificity | NA |
AUC | NA |
Accuracy | NA |
Level Of Significance | Univariate: Cohort 1+2: p=0.02;Multivariate: Cohort 1: p = 0.03; Cohort 1+2: p=0.007 |
Method Used | MALDI-TOF |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Validated on independent patient dataset |
Technical Name | NA |