| Biomarker ID | 1413 |
| PMID | 24740842 |
| Year | 2014 |
| Biomarker | CDON [SNP: rs3737336: CC vs. TT/TC] |
| Biomarker Basis | Mutation Based |
| Biomolecule | Mutation |
| Source | Blood |
| Subjects | Humans |
| Regulation | NA |
| Odds Ratio/Hazard Ratio/Relative Risk | HR: Univariate: Cohort 1+2: [1.54 (95% CI: 1.1.07–2.20)]HR: Multivariate: Cohort 1: [1.95 (95% CI: 1.09–3.51)]; Cohort 1+2: [1.72 (95% CI: 1.16–2.55)] |
| Effect on Pathways | Pathways include: Signaling events mediated by the hedgehog family, CDO in myogenesis, Hedgehog signaling pathway, Developmental biology |
| Experiment | Biochemical recurrence Vs No Biochemical Recurrence |
| Type of Biomarker | Prognostic |
| Cohort | two independent cohorts composed of 320 Asian and 526 Caucasian men with pathologically organ-confined prostate cancer were selected |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | Univariate: Cohort 1+2: p=0.02;Multivariate: Cohort 1: p = 0.03; Cohort 1+2: p=0.007 |
| Method Used | MALDI-TOF |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Validated on independent patient dataset |
| Technical Name | NA |