| Biomarker ID | 1407 |
| PMID | 24740842 |
| Year | 2014 |
| Biomarker | MIR605 [SNP: rs2043556: GG] |
| Biomarker Basis | Mutation Based |
| Biomolecule | Mutation |
| Source | Blood |
| Subjects | Humans |
| Regulation | NA |
| Odds Ratio/Hazard Ratio/Relative Risk | HR: Univariate: Cohort 1: [2.23 (95% CI: 1.25–3.97)]; Cohort 1+2: [1.88 (95% CI: 1.16–3.06)]HR: Multivariate: Cohort 1: [2.62 (95% CI: 1.33–5.15)]; Cohort 1+2: [2.03 (95% CI: 1.18–3.50)] |
| Effect on Pathways | Pathways include: phosphorylation; dendritic spine; actin filament organization; formation of primary germ layer; germ cell migration |
| Experiment | Biochemical recurrence Vs No Biochemical Recurrence |
| Type of Biomarker | Prognostic |
| Cohort | two independent cohorts composed of 320 Asian and 526 Caucasian men with pathologically organ-confined prostate cancer were selected |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | Univariate: Cohort 1: p= 0.006 Cohort 1+2: p=0.01;Multivariate: Cohort 1:p = 0.005 Cohort 1+2: p=0.01 |
| Method Used | MALDI-TOF |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Validated on independent patient dataset |
| Technical Name | NA |