Biomarker ID | 1405 |
PMID | 24737792 |
Year | 2014 |
Biomarker | OAZ2 |
Biomarker Basis | RNA expression |
Biomolecule | mRNA |
Source | Tissue |
Subjects | Humans |
Regulation | Downregulated in PCa |
Odds Ratio/Hazard Ratio/Relative Risk | Cohort 1 : Univariate: HR: 56.76 (95% CI: 9.04-356.44), p-value <0.001, C-Index= 0.68; Multivariate: HR= 123.41 (95% CI:1.34-11383.85), p-value= 0.037, C-Index=0.85; |
Effect on Pathways | Pathways include: Ubiquitin-mediated degradation of phosphorylated Cdc25A; Amino acid metabolism |
Experiment | Biochemical recurrence Vs No Biochemical Recurrence |
Type of Biomarker | Prognostic |
Cohort | 30 nonmalignant and 30 prostate cancer tissue samples were used for this analysis |
Senstivity | 95.5% |
Specificity | 94.3% |
AUC | 0.98 |
Accuracy | NA |
Level Of Significance | p=0.001 |
Method Used | Training: Microarray; Validation: qRT-PCR |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Validated on independent patient dataset |
Technical Name | NA |