| Biomarker ID | 1400 |
| PMID | 24737792 |
| Year | 2014 |
| Biomarker | Methylation status of GABRE + miR-224 +miR-452 (High vs. Low ) |
| Biomarker Basis | Methylation Based |
| Biomolecule | miRNA + Methylation |
| Source | Tissue |
| Subjects | Humans |
| Regulation | Hypermethylated in PCa |
| Odds Ratio/Hazard Ratio/Relative Risk | Cohort 1: Univariate: HR: 1.80 (95% CI:1.26-2.57), p-value= 0.001, C-Index= 0.57; Multivariate: 1.47 (95% CI:1.02-2.13), p-value = 0.040, C-Index=0.73; Cohort 2: Univariate: HR: 2.54 (95% CI: 1.68-3.84), p-value <0.001, C-Index= 0.62; Multivariate: HR=2.03 (95% CI:1.30-3.17), p-value= 0.002, C-index= 0.75 |
| Effect on Pathways | NA |
| Experiment | Biochemical recurrence Vs No Biochemical Recurrence |
| Type of Biomarker | Prognostic |
| Cohort | Cohort 1: 293 Patients with 170 having no recurrence and 123 experiencing recurrence were included.Cohort 2: 198 Patients with 103 having no recurrence and 95 experiencing recurrence were included |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | Cohort 1: 0.74; Cohort 2: 0.77 |
| Level Of Significance | Cohort 1: Univariate: p<0.001; Multivariate: p= 0.019 Cohort 2: Univariate: p<0.001; Multivariate: p=0.008 |
| Method Used | Training: Microarray; Validation: qRT-PCR |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Validated on independent patient dataset |
| Technical Name | NA |