| Biomarker ID | 1375 |
| PMID | 24708576 |
| Year | 2014 |
| Biomarker | MAP4K4 |
| Biomarker Basis | Expression Based |
| Biomolecule | Protein |
| Source | Tissue |
| Subjects | Humans |
| Regulation | NA |
| Odds Ratio/Hazard Ratio/Relative Risk | Multivariate: HR: 1.76 (95% CI:1.08-2.86) |
| Effect on Pathways | Pathways include: NF-kappaB activation by non-typeable Hemophilus influenzae, Signal transduction through IL-1R, Ephrin receptor B forward pathway, TNF/stress-related signaling, Ceramide signaling pathway |
| Experiment | Biochemical Failure Vs No Biochemical Faliure |
| Type of Biomarker | Prognostic |
| Cohort | 160 patients with PCa were selected for the analysis |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p=0.024 |
| Method Used | Immunohistochemistry |
| Clinical | No |
| Remarks | Time to BF was calculated from date of prostatectomy to the date of known BF, defined as the date of a PSA value ≥0.2 ng/mL (taken at least 6 weeks after surgery) and confirmed by a second PSA value >0.2 ng/mL. Time to BF was censored at the last date of contact for subjects who did not experience BF. |
| Clinical Trial Number | NA |
| Degree Of Validity | Validated on independent patient dataset |
| Technical Name | NA |