Biomarker ID | 1351 |
PMID | 24607843 |
Year | 2014 |
Biomarker | miR-221 |
Biomarker Basis | Expression Based |
Biomolecule | miRNA |
Source | Tissue |
Subjects | Humans |
Regulation | Downregulation in high-risk prostate cancer |
Odds Ratio/Hazard Ratio/Relative Risk | Cohort 2: HR: 0.026 (95% CI: 0.003–0.201) |
Effect on Pathways | Pathway Include: homophilic cell adhesion via plasma membrane adhesion molecules; transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; DNA binding; synapse |
Experiment | Cancer Related Death Vs No Cancer Related Death |
Type of Biomarker | Prognostic |
Cohort | Cohort 1 included 134 patients with 11 cancer related deaths and Cohort 2 included 89 patients with 15 cancer related deaths |
Senstivity | NA |
Specificity | NA |
AUC | Cohort 1: 90.28% (95% CI: 83.95%–96.61%) |
Accuracy | NA |
Level Of Significance | p<0.0001 |
Method Used | qRT-PCR |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Validated on independent patient dataset |
Technical Name | NA |