Biomarker ID | 1336 |
PMID | 24518785 |
Year | 2014 |
Biomarker | PSA+PCA3+miR-187 |
Biomarker Basis | Expression Based |
Biomolecule | miRNA |
Source | Tissue |
Subjects | Humans |
Regulation | Downregulated in PCa (12 fold) |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways Include: synapse; cell morphogenesis involved in differentiation; cell morphogenesis involved in neuron differentiation; asymmetric synapse; endosome; Pathways Include (KLK3) :-ID regulation of gene expression,Prostate cancer, Androgen receptor proteolysis and transcription regulation, Androgen receptor signaling, proteolysis, and transcription regulation, Insulin-like growth factor (IGF) activity regulation by insulin-like growth factor binding proteins (IGFBPs) |
Experiment | Prostate Cancer Vs Normal Prostate |
Type of Biomarker | Diagnostic |
Cohort | Total of 92 samples - 45 negative and 47 positive were selected for the study |
Senstivity | 88.6% (95% CI 78.1- 99.2) |
Specificity | 50% (95% CI 34.1- 65.9) |
AUC | 0.711 (95% CI 0.603 - 0.819) |
Accuracy | 69.3% (95% CI 59.1 - 79.5) |
Level Of Significance | p<0.05 |
Method Used | qRT-PCR |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Validated on independent patient dataset |
Technical Name | KLK3, PCA3, miR-187 |