Biomarker ID | 1324 |
PMID | 24477576 |
Year | 2014 |
Biomarker | miR-628-5p |
Biomarker Basis | Expression Based |
Biomolecule | miRNA |
Source | Serum |
Subjects | Humans |
Regulation | Downregulated in PCa |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways Include: cation binding; metal ion binding; DNA-binding transcription factor activity; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific |
Experiment | African Americans Vs Caucasian Americans with PCa |
Type of Biomarker | Diagnostic |
Cohort | 40 PCa patients (16 Caucasian American) and (24 African Americans) along with 32 controls (20 Caucasian American) and (12 African Americans) were selected for analysis |
Senstivity | NA |
Specificity | NA |
AUC | 0.94 (95% CI: 0.90-0.99) |
Accuracy | NA |
Level Of Significance | p<0.0001 |
Method Used | qRT-PCR |
Clinical | No |
Remarks | Also significantly downregulated when only Caucasian American or only African American population is considered alone |
Clinical Trial Number | NA |
Degree Of Validity | Validated on independent patient dataset |
Technical Name | miR-628-5p |