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Biomarker Card

This biomarker card gives comprehensive information about each biomarker.
Detailed Information
Biomarker ID1315
PMID24411283
Year2014
BiomarkerKLK3 [SNP: rs2735839]
Biomarker BasisMutation Based
BiomoleculeMutation
SourceBlood
SubjectsHumans
RegulationDecreased risk of PCa Specific Mortality
Odds Ratio/Hazard Ratio/Relative RiskHR: 0.82 (95% CI: 0.73–0.93)
Effect on PathwaysPathways include: ID regulation of gene expression, Prostate cancer, Androgen receptor proteolysis and transcription regulation, Androgen receptor signaling, proteolysis, and transcription regulation, Insulin-like growth factor (IGF) activity regulation by insulin-like growth factor binding proteins (IGFBPs)
ExperimentPCa Specific Mortality Vs No Mortality
Type of BiomarkerPrognostic
Cohort8 different cohorts from The Breast and Prostate Cancer Cohort Consortium were studied in this analysis. Overall 10487 cases were included out of which 1053 had PCa related deaths
SenstivityNA
SpecificityNA
AUCNA
AccuracyNA
Level Of Significancep=0.002
Method UsedNA
ClinicalNo
RemarksNA
Clinical Trial NumberNA
Degree Of ValidityNot validated on independent patient dataset
Technical NameNA