Biomarker ID | 1248 |
PMID | 24255071 |
Year | 2013 |
Biomarker | Thrombospondin-1 [TSP-1] |
Biomarker Basis | Concentration Based (μg/L) |
Biomolecule | Protein |
Source | Plasma |
Subjects | Humans |
Regulation | Increased levels indicate better overall survival in Tasquinimod arm |
Odds Ratio/Hazard Ratio/Relative Risk | HR: 0.54 |
Effect on Pathways | NA |
Experiment | Overall Survival in Tasquinimod Vs Overall Survival in Placebo arm |
Type of Biomarker | Predictive |
Cohort | 201 patients with Prostate cancer were defined as the cohort. They were randomised into 134 tasquinimod and 67 placebo arms. |
Senstivity | NA |
Specificity | NA |
AUC | NA |
Accuracy | NA |
Level Of Significance | p=0.034 |
Method Used | ELISA |
Clinical | Yes |
Remarks | (n= 95) TSP1 ≤ 1370 μg/L and (n=94) TSP1 >1370 μg/L were chosen as the classification Criteria |
Clinical Trial Number | NCT00560482 |
Degree Of Validity | Not validated on independent patient dataset |
Technical Name | NA |