Biomarker ID | 1227 |
PMID | 24167554 |
Year | 2013 |
Biomarker | miR-221 |
Biomarker Basis | Expression Based |
Biomolecule | miRNA |
Source | Tissue |
Subjects | Humans |
Regulation | Downregulated in PCa |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways Include:-homophilic cell adhesion via plasma membrane adhesion molecules; transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; DNA binding; synapse |
Experiment | Prostate Cancer Vs Adjacent Normal |
Type of Biomarker | Diagnostic |
Cohort | 40 PCa patients with Gleason (GS) 6–7 and adjacent normal regions were profiled (including the 10 in discovery set) |
Senstivity | NA |
Specificity | NA |
AUC | 0.75 (95% CI: 0.63–0.84) |
Accuracy | NA |
Level Of Significance | p<0.001 |
Method Used | qRT-PCR |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Validated on independent patient dataset |
Technical Name | miR-221 |