Biomarker ID | 1201 |
PMID | 23935962 |
Year | 2013 |
Biomarker | miR-200a |
Biomarker Basis | Expression Based |
Biomolecule | miRNA |
Source | Serum |
Subjects | Humans |
Regulation | Upregulated in PCa [Cohort 1: 6.1 fold; Cohort 2: 1.76 fold] |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways Include:- regulation of RNA metabolic process; Gene expression (Transcription); MicroRNAs in cancer;DNA-binding transcription factor activity, RNA polymerase II-specific; nuclear chromosome |
Experiment | Controls Vs Metastatic Castration Resistant Prostate Cancer (mCRPC) |
Type of Biomarker | Diagnostic |
Cohort | Cohort 1: mCRPC patients (n=25) Vs age matched controls (n = 25);Cohort 2: 21 mCRPC patients and 20 age-matched healthy controls collected at the University of Michigan. |
Senstivity | NA |
Specificity | NA |
AUC | Cohort 1: 0.699; Cohort 2: 0.638 |
Accuracy | NA |
Level Of Significance | Training: p=0.007; Testing: p=NS |
Method Used | qRT-PCR |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Validated on independent patient dataset |
Technical Name | miR-200a |