| Biomarker ID | 1200 |
| PMID | 23935962 |
| Year | 2013 |
| Biomarker | miR-141 |
| Biomarker Basis | Expression Based |
| Biomolecule | miRNA |
| Source | Serum |
| Subjects | Humans |
| Regulation | Upregulated in PCa [Cohort 1: 27.9 fold; Cohort 2: 5.1 fold] |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include:- regulation of RNA metabolic process; Gene expression (Transcription); RNA Polymerase II Transcription; nuclear chromosome; DNA-binding transcription factor activity, RNA polymerase II-specific |
| Experiment | Controls Vs Metastatic Castration Resistant Prostate Cancer (mCRPC) |
| Type of Biomarker | Diagnostic |
| Cohort | Cohort 1: mCRPC patients (n=25) Vs age matched controls (n = 25);Cohort 2: 21 mCRPC patients and 20 age-matched healthy controls collected at the University of Michigan. |
| Senstivity | NA |
| Specificity | NA |
| AUC | Cohort 1: 0.899; Cohort 2: 0.842 |
| Accuracy | NA |
| Level Of Significance | Training: p<0.0001; Testing: p<0.001 |
| Method Used | qRT-PCR |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Validated on independent patient dataset |
| Technical Name | miR-141 |