| Biomarker ID | 1197 |
| PMID | 23918943 |
| Year | 2013 |
| Biomarker | Methylation Status of AOX1/C1orf114/HAPLN3 |
| Biomarker Basis | Methylation Based |
| Biomolecule | Methylation |
| Source | Tissue |
| Subjects | Humans |
| Regulation | Lower Methylation in Patients with Longer Survival |
| Odds Ratio/Hazard Ratio/Relative Risk | Cohort 1: Univariate: [HR= 2.91 (95% CI: 2.03-4.17), pvalue<0.001, AUC = 0.70 ]; Multivariate: [HR = 2.11 (95% CI:1.40-3.17), P-value <0.001, AUC=0.84];Cohort 2: Univariate: [HR= 2.53 (95% CI:1.48-4.33), p-value < 0.001, AUC= 0.67]; Multivariate: [HR=2.26 (95% CI: 1.27-4.01), p-value= 0.005, AUC=0.86] |
| Effect on Pathways | NA |
| Experiment | Biochemical recurrence |
| Type of Biomarker | Prognostic |
| Cohort | Cohort 1: 293 patients were included in the study, 170 without Recurrence and 123 with Recurrence were included in the study. Cohort 2: 114 patients - 58 having no recurrence and 56 having recurrence were included in te study |
| Senstivity | NA |
| Specificity | NA |
| AUC | Cohort 1: Univariate: 0.69; Multivariate: 0.828;Cohort 2: Univariate: 0.70 ; Multivariate: 0.906 |
| Accuracy | NA |
| Level Of Significance | NA |
| Method Used | quantitative methylation specific PCR |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Validated on independent patient dataset |
| Technical Name | C1orf114/HAPLN3 |