Biomarker ID | 1196 |
PMID | 23918943 |
Year | 2013 |
Biomarker | Methylation Status of AOX1/C1orf114/HAPLN3 |
Biomarker Basis | Methylation Based |
Biomolecule | Methylation |
Source | Tissue |
Subjects | Humans |
Regulation | Lower Methylation in Patients with Longer Survival |
Odds Ratio/Hazard Ratio/Relative Risk | Cohort 1: Univariate: [2.58 (95% CI: 1.79 to 3.71)]; Multivariate: [1.91 (95% CI: 1.26 to 2.90];Cohort 2: Univariate: [2.64 (95% CI: 1.55 to 4.51)]; Multivariate: [2.33 (95% CI: 1.31 to 4.13)] |
Effect on Pathways | NA |
Experiment | Biochemical recurrence |
Type of Biomarker | Prognostic |
Cohort | Cohort 1: 293 patients were included in the study, 170 without Recurrence and 123 with Recurrence were included in the study. Cohort 2: 114 patients - 58 having no recurrence and 56 having recurrence were included in te study |
Senstivity | NA |
Specificity | NA |
AUC | Cohort 1: Univariate: 0.69; Multivariate: 0.828;Cohort 2: Univariate: 0.70 ; Multivariate: 0.906 |
Accuracy | NA |
Level Of Significance | NA |
Method Used | quantitative methylation specific PCR |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Validated on independent patient dataset |
Technical Name | AOX1/C1orf114/HAPLN3 |