| Biomarker ID | 1193 |
| PMID | 23918943 |
| Year | 2013 |
| Biomarker | Methylation Status of KLF8 (High vs. Low) |
| Biomarker Basis | Methylation Based |
| Biomolecule | Methylation |
| Source | Tissue |
| Subjects | Humans |
| Regulation | Hypermethylated in Prostate Cancer |
| Odds Ratio/Hazard Ratio/Relative Risk | Cohort 1: univariate : [HR = 2.16 (95% CI: 1.35-3.47) p-value= 0.001, AUC = 0.57]; multivariate : [HR = 1.32 (95% CI: 0.77-2.24), p-value = 0.314]; Cohort 2: univariate : [HR = 1.44 (95% CI: 0.652-3.196), p-value= 0.365, AUC= 0.55] |
| Effect on Pathways | Pathways include: Signaling events mediated by focal adhesion kinase |
| Experiment | Biochemical recurrence |
| Type of Biomarker | Prognostic |
| Cohort | Nonmalignant samples [(adjacent normal [ADJ-N], benign prostatic hyperplasia (BPH)( n = 35)] and radical prostatectomy (RP) samples (n = 293) were chosen for the study |
| Senstivity | NA |
| Specificity | NA |
| AUC | 0.956 |
| Accuracy | NA |
| Level Of Significance | P < 0.001 |
| Method Used | quantitative methylation specific PCR |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Validated on independent patient dataset |
| Technical Name | KLF8 |