| Biomarker ID | 1142 |
| PMID | 23798998 |
| Year | 2013 |
| Biomarker | let-7a; let-7b; let-7c |
| Biomarker Basis | Expression Based |
| Biomolecule | miRNA |
| Source | Tissue |
| Subjects | Humans |
| Regulation | Downregulated in PCa: [let-7a; let-7b; let-7c] |
| Odds Ratio/Hazard Ratio/Relative Risk | NA |
| Effect on Pathways | Pathways Include(let-7a):- nucleoplasm; regulation of RNA metabolic process; DNA-binding transcription factor activity, RNA polymerase II-specific; regulation of nucleic acid-templated transcriptionregulation of transcription, DNA-templated Pathways Include(let-7c):- regulation of RNA metabolic process; regulation of nucleic acid-templated transcription; regulation of RNA biosynthetic process; RNA biosynthetic process; regulation of transcription, DNA-templated |
| Experiment | Prostate Cancer Vs Benign Prostatic Hyperplasia |
| Type of Biomarker | Diagnostic |
| Cohort | 98 patients with Prostate cancer were chosen for the study out of which 18 experienced clincal failure and 80 did not |
| Senstivity | NA |
| Specificity | NA |
| AUC | NA |
| Accuracy | NA |
| Level Of Significance | p<0.01 |
| Method Used | RT-PCR |
| Clinical | No |
| Remarks | NA |
| Clinical Trial Number | NA |
| Degree Of Validity | Validated on independent patient dataset |
| Technical Name | let-7a, let-7b, let-7c |