Biomarker ID | 1142 |
PMID | 23798998 |
Year | 2013 |
Biomarker | let-7a; let-7b; let-7c |
Biomarker Basis | Expression Based |
Biomolecule | miRNA |
Source | Tissue |
Subjects | Humans |
Regulation | Downregulated in PCa: [let-7a; let-7b; let-7c] |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways Include(let-7a):- nucleoplasm; regulation of RNA metabolic process; DNA-binding transcription factor activity, RNA polymerase II-specific; regulation of nucleic acid-templated transcriptionregulation of transcription, DNA-templated Pathways Include(let-7c):- regulation of RNA metabolic process; regulation of nucleic acid-templated transcription; regulation of RNA biosynthetic process; RNA biosynthetic process; regulation of transcription, DNA-templated |
Experiment | Prostate Cancer Vs Benign Prostatic Hyperplasia |
Type of Biomarker | Diagnostic |
Cohort | 98 patients with Prostate cancer were chosen for the study out of which 18 experienced clincal failure and 80 did not |
Senstivity | NA |
Specificity | NA |
AUC | NA |
Accuracy | NA |
Level Of Significance | p<0.01 |
Method Used | RT-PCR |
Clinical | No |
Remarks | NA |
Clinical Trial Number | NA |
Degree Of Validity | Validated on independent patient dataset |
Technical Name | let-7a, let-7b, let-7c |