Biomarker ID | 1043 |
PMID | 23342084 |
Year | 2013 |
Biomarker | Early Growth Response 3 (Egr3) |
Biomarker Basis | Expression Based |
Biomolecule | Protein |
Source | Tissue |
Subjects | Humans |
Regulation | Upregulated in PCa (NSR (number of strong positive pixels ratio):normal prostate: 0.039 ; NSR: prostate cancer: 0.13) |
Odds Ratio/Hazard Ratio/Relative Risk | NA |
Effect on Pathways | Pathways include: Inhibition of activated T cell apoptosis by neuropeptides VIP and PACAP, Regulation of NFAT transcription factors, Differentiation pathway in PC12 cells, Interleukin-5 regulation of apoptosis, BDNF signaling pathway |
Experiment | Prostate Cancer Vs Normal Prostate |
Type of Biomarker | Diagnostic |
Cohort | 20 prostate cancer samples from 11 patients and 3 normal prostate samples from 3 donors were chosen. (taken from The Human Protein Atlas (HPA): HPA006206) |
Senstivity | NA |
Specificity | NA |
AUC | NA |
Accuracy | NA |
Level Of Significance | p = 0.00047 |
Method Used | NA |
Clinical | No |
Remarks | NSR: (number of strong positive pixels ratio): strong positive pixels/total positive pixels |
Clinical Trial Number | NA |
Degree Of Validity | Validated on independent patient dataset |
Technical Name | NA |