Browse By Oncolytic Virus Species Result Page of OvirusTdb
The Total number of records shown on this page is 2. Click on ID to see further detail.
IDOV_323 | Virus nameCanine parvovirus | Virus strainCPV2.NS1 | Virus genome typeDNA | Virus familyParoviridae | Virus genome modificationCPV genome expressing non-structural protein (NS1) | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNCCS (National Centre for Cell Science, Pune, India) | Origin of cell lineHuman cervical cancer cell line | Cell lineHeLa | Concentration of cell linedensity of E+4 to E+5 cells/well in 120 microlitres of culture medium | In-vitro toxicityNA | AssayLDH assay | In-vitro virus concentrationNA | In-vitro result9% cancer cell death at 24 hours | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedApoptosis is induced via mitochondrial depolarization, release of cytochrome-c and activation of caspase 9 | Immunogenic effectNA | Clinical trialNA | PMID26555166 |
IDOV_324 | Virus nameCanine parvovirus | Virus strainCPV2.NS1 | Virus genome typeDNA | Virus familyParoviridae | Virus genome modificationCPV genome expressing non-structural protein (NS1) | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNCCS (National Centre for Cell Science, Pune, India) | Origin of cell lineHuman cervical cancer cell line | Cell lineHeLa | Concentration of cell linedensity of E+4 to E+5 cells/well in 120 microlitres of culture medium | In-vitro toxicityNA | AssayLDH assay | In-vitro virus concentrationNA | In-vitro result18% cancer cell death at 48 hours | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedApoptosis is induced via mitochondrial depolarization, release of cytochrome-c and activation of caspase 9 | Immunogenic effectNA | Clinical trialNA | PMID26555166 |