Browse By Oncolytic Virus Species Result Page of OvirusTdb

The Total number of records shown on this page is 2. Click on ID to see further detail.
IDOV_323Virus nameCanine parvovirusVirus strainCPV2.NS1Virus genome typeDNAVirus familyParoviridaeVirus genome modificationCPV genome expressing non-structural protein (NS1)Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNCCS (National Centre for Cell Science, Pune, India)Origin of cell lineHuman cervical cancer cell lineCell lineHeLaConcentration of cell linedensity of E+4 to E+5 cells/well in 120 microlitres of culture mediumIn-vitro toxicityNAAssayLDH assayIn-vitro virus concentrationNAIn-vitro result9% cancer cell death at 24 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedApoptosis is induced via mitochondrial depolarization, release of cytochrome-c and activation of caspase 9Immunogenic effectNAClinical trialNAPMID26555166
IDOV_324Virus nameCanine parvovirusVirus strainCPV2.NS1Virus genome typeDNAVirus familyParoviridaeVirus genome modificationCPV genome expressing non-structural protein (NS1)Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNCCS (National Centre for Cell Science, Pune, India)Origin of cell lineHuman cervical cancer cell lineCell lineHeLaConcentration of cell linedensity of E+4 to E+5 cells/well in 120 microlitres of culture mediumIn-vitro toxicityNAAssayLDH assayIn-vitro virus concentrationNAIn-vitro result18% cancer cell death at 48 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedApoptosis is induced via mitochondrial depolarization, release of cytochrome-c and activation of caspase 9Immunogenic effectNAClinical trialNAPMID26555166