Browse By Oncolytic Virus Species Result Page of OvirusTdb

The Total number of records shown on this page is 10. Click on ID to see further detail.
IDOV_4646Virus nameBovine herpesvirusVirus strainBHV-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus in combination with 5-AZa (0.5 micromolar/litre)Immune gene insertion in viral genomeNoSource of cell lineSt. Louis universityOrigin of cell lineCotton rat tumor cell lineCell lineLCRTConcentration of cell line1.0E+5 cells per mlIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result87% cell viablity after 2 days, additive effectModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduce antitumor immune responseClinical trialNAPMID27119103
IDOV_4647Virus nameBovine herpesvirusVirus strainBHV-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus in combination with 5-AZa (0.5 micromolar/litre)Immune gene insertion in viral genomeNoSource of cell lineSt. Louis universityOrigin of cell lineCotton rat tumor cell lineCell lineLCRTConcentration of cell line1.0E+5 cells per mlIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration3 MOIIn-vitro result80% cell viablity after 2 days, additive effectModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduce antitumor immune responseClinical trialNAPMID27119103
IDOV_4648Virus nameBovine herpesvirusVirus strainBHV-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus in combination with 5-AZa (0.5 micromolar/litre)Immune gene insertion in viral genomeNoSource of cell lineSt. Louis universityOrigin of cell lineCotton rat tumor cell lineCell lineLCRTConcentration of cell line1.0E+5 cells per mlIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration5 MOIIn-vitro result56% cell viablity after 2 days, additive effectModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduce antitumor immune responseClinical trialNAPMID27119103
IDOV_4649Virus nameBovine herpesvirusVirus strainBHV-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus in combination with 5-AZa (1.0 micromolar/litre)Immune gene insertion in viral genomeNoSource of cell lineSt. Louis universityOrigin of cell lineCotton rat tumor cell lineCell lineLCRTConcentration of cell line1.0E+5 cells per mlIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result74% cell viablity after 2 days, additive effectModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduce antitumor immune responseClinical trialNAPMID27119103
IDOV_4650Virus nameBovine herpesvirusVirus strainBHV-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus in combination with 5-AZa (1.0 micromolar/litre)Immune gene insertion in viral genomeNoSource of cell lineSt. Louis universityOrigin of cell lineCotton rat tumor cell lineCell lineLCRTConcentration of cell line1.0E+5 cells per mlIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration3 MOIIn-vitro result79% cell viablity after 2 days, additive effectModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduce antitumor immune responseClinical trialNAPMID27119103
IDOV_4651Virus nameBovine herpesvirusVirus strainBHV-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus in combination with 5-AZa (1.0 micromolar/litre)Immune gene insertion in viral genomeNoSource of cell lineSt. Louis universityOrigin of cell lineCotton rat tumor cell lineCell lineLCRTConcentration of cell line1.0E+5 cells per mlIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration5 MOIIn-vitro result56% cell viablity after 2 days, additive effectModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduce antitumor immune responseClinical trialNAPMID27119103
IDOV_4652Virus nameBovine herpesvirusVirus strainBHV-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus in combination with 5-AZa (3.0 micromolar/litre)Immune gene insertion in viral genomeNoSource of cell lineSt. Louis universityOrigin of cell lineCotton rat tumor cell lineCell lineLCRTConcentration of cell line1.0E+5 cells per mlIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result59% cell viablity after 2 days, additive effectModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduce antitumor immune responseClinical trialNAPMID27119103
IDOV_4653Virus nameBovine herpesvirusVirus strainBHV-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus in combination with 5-AZa (3.0 micromolar/litre)Immune gene insertion in viral genomeNoSource of cell lineSt. Louis universityOrigin of cell lineCotton rat tumor cell lineCell lineLCRTConcentration of cell line1.0E+5 cells per mlIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration3 MOIIn-vitro result60% cell viablity after 2 days, additive effectModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduce antitumor immune responseClinical trialNAPMID27119103
IDOV_4654Virus nameBovine herpesvirusVirus strainBHV-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus in combination with 5-AZa (3.0 micromolar/litre)Immune gene insertion in viral genomeNoSource of cell lineSt. Louis universityOrigin of cell lineCotton rat tumor cell lineCell lineLCRTConcentration of cell line1.0E+5 cells per mlIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration5 MOIIn-vitro result60% cell viablity after 2 days, additive effectModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectInduce antitumor immune responseClinical trialNAPMID27119103
IDOV_4655Virus nameBovine herpesvirusVirus strainBHV-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNoneVirus aloneNoVirus in combination with drug/radiationVirus in combination with 5-AZa (2mg/kg) intraperitoneal single doseImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismCR mice xenograft for LCRT cells (5.0E+5)In-vivo virus concentration5.0E+6 pfu for 5 daysIn-vivo toxicityNA In-vivo resultCombination therapy results in 3/8 animals with delayed growthMode of deliveryIntratumoralPathway inducedNAImmunogenic effectInduce antitumor immune responseClinical trialNAPMID27119103