The Total number of records shown on this page is 26. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_4235	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c AnNcrj-nu/nu female mice xenograft for SK-N-SH (1.0E+6)	1.0E+6 pfu	NA	Reduction in tumor volume to 1000 cubic millimeter in mice 1 after 56 days	Intravenous	Virus induce apoptosis process leads to cancer cell death	Increased expression of Bcl-2 and Bcl-xL expression	NA	26298056
OV_4236	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c AnNcrj-nu/nu female mice xenograft for SK-N-SH (1.0E+6)	1.0E+6 pfu	NA	Complete reduction in tumor volume after 28 days in mice 2	Intravenous	Virus induce apoptosis process leads to cancer cell death	Increased expression of Bcl-2 and Bcl-xL expression	NA	26298056
OV_4237	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c AnNcrj-nu/nu female mice xenograft for SK-N-SH (1.0E+6)	1.0E+6 pfu	NA	Complete reduction in tumor volume after 28 days in mice 3	Intravenous	Virus induce apoptosis process leads to cancer cell death	Increased expression of Bcl-2 and Bcl-xL expression	NA	26298056
OV_4238	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c AnNcrj-nu/nu female mice xenograft for SK-N-SH (1.0E+6)	1.0E+6 pfu	NA	Complete reduction in tumor volume after 28 days in mice 4	Intravenous	Virus induce apoptosis process leads to cancer cell death	Increased expression of Bcl-2 and Bcl-xL expression	NA	26298056
OV_4239	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c AnNcrj-nu/nu female mice xenograft for SK-N-SH (1.0E+6)	1.0E+6 pfu	NA	Complete reduction in tumor volume after 48 days in mice 5	Intravenous	Virus induce apoptosis process leads to cancer cell death	Increased expression of Bcl-2 and Bcl-xL expression	NA	26298056
OV_4240	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c AnNcrj-nu/nu female mice xenograft for SK-N-SH (1.0E+6)	1.0E+6 pfu	NA	Complete reduction in tumor volume after 56 days in mice 6	Intravenous	Virus induce apoptosis process leads to cancer cell death	Increased expression of Bcl-2 and Bcl-xL expression	NA	26298056
OV_4241	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c AnNcrj-nu/nu female mice xenograft for SK-N-SH (1.0E+6)	1.0E+6 pfu	NA	Complete reduction in tumor volume after 56 days in mice 7	Intravenous	Virus induce apoptosis process leads to cancer cell death	Increased expression of Bcl-2 and Bcl-xL expression	NA	26298056
OV_5557	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	Human keratinocytes	EN60	1.0E+5 cells per well	NA	NA	1 MOI	Significant death of cancer cell line after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5558	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	Human pancreatic cell line	SUIT-2	1.0E+5 cells per well	NA	NA	1 MOI	Significant death of cancer cell line after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5559	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	Human pancreatic cell line	BxPC-3	1.0E+5 cells per well	NA	NA	1 MOI	Significant death of cancer cell line after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5560	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	Human pancreatic cell line	PANC-1	1.0E+5 cells per well	NA	NA	1 MOI	Significant death of cancer cell line after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5561	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	Human pancreatic cell line	MIAPaCa-2	1.0E+5 cells per well	NA	NA	1 MOI	Significant death of cancer cell line after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5567	Sindbis virus	AR339	RNA	Togaviridae	None	No	Sindbis virus in combination with Reovirus	No	NA	Human keratinocytes	EN60	1.0E+5 cells per well	NA	NA	1 MOI	Enhancer cytolytic effect in combination after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5568	Sindbis virus	AR339	RNA	Togaviridae	None	No	Sindbis virus in combination with Reovirus	No	NA	Human pancreatic cell line	SUIT-2	1.0E+5 cells per well	NA	NA	1 MOI	Enhancer cytolytic effect in combination after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5569	Sindbis virus	AR339	RNA	Togaviridae	None	No	Sindbis virus in combination with Reovirus	No	NA	Human pancreatic cell line	BxPC-3	1.0E+5 cells per well	NA	NA	1 MOI	Enhancer cytolytic effect in combination after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5570	Sindbis virus	AR339	RNA	Togaviridae	None	No	Sindbis virus in combination with Reovirus	No	NA	Human pancreatic cell line	PANC-1	1.0E+5 cells per well	NA	NA	1 MOI	Enhancer cytolytic effect in combination after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5571	Sindbis virus	AR339	RNA	Togaviridae	None	No	Sindbis virus in combination with Reovirus	No	NA	Human pancreatic cell line	MIAPaCa-2	1.0E+5 cells per well	NA	NA	1 MOI	Enhancer cytolytic effect in combination after 72 hours	No	No	NA	No response	NA	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5572	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	Human pancreatic cell line	SUIT-2	NA	NA	NA	NA	NA	Nude mice xenografted subcutaneously for SUIT-2	1.0E+6 pfu	NA	Tumor volume reduced to below 3.0 cm after 10 weeks	Intratumoral	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5574	Sindbis virus	AR339	RNA	Togaviridae	None	No	Sindbis virus in combination with Reovirus	No	NA	Human pancreatic cell line	SUIT-2	NA	NA	NA	NA	NA	Nude mice xenografted subcutaneously for SUIT-2	1.0E+6 pfu	NA	Tumor volume reduced to below 0.5 cm after 10 weeks	Intratumoral	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5575	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	Human pancreatic cell line	BxPC-3	NA	NA	NA	NA	NA	Nude mice xenografted subcutaneously for BxPC3	1.0E+6 pfu	NA	Tumor volume reduced to below 2.0 cm after 10 weeks	Intratumoral	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5577	Sindbis virus	AR339	RNA	Togaviridae	None	No	Sindbis virus in combination with Reovirus	No	NA	Human pancreatic cell line	BxPC-3	NA	NA	NA	NA	NA	Nude mice xenografted subcutaneously for BxPC3	1.0E+6 pfu	NA	Complete reduction in tumor volume after 10 weeks	Intratumoral	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5578	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	Human pancreatic cell line	BxPC-3	NA	NA	NA	NA	NA	Nude mice xenografted subcutaneously for MIAPaCa-2	1.0E+6 pfu	NA	Tumor volume reduced to below 5.0 cm after 12 weeks	Intratumoral	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5580	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	Human eosophageal cancer cell line	YES-6	NA	NA	NA	NA	NA	Mice xenografted for eosophageal cancer cell line YES-6	1.0E+6 pfu	NA	Complete reduction in tumor volume after 28 weeks	Intratumoral	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5581	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	Human eosophageal cancer cell line	YES-6	NA	NA	NA	NA	NA	Mice xenografted for eosophageal cancer cell line YES-6	1.0E+6 pfu	NA	Complete reduction in tumor volume after 28 weeks	Intraperitoneal	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5582	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	Human eosophageal cancer cell line	TTn	NA	NA	NA	NA	NA	Mice xenografted for eosophageal cancer cell line TTn	1.0E+6 pfu	NA	Tumor volume reduced to below 500mm after 32 weeks	Intratumoral	Induction of apoptosis by virus infection	NA	NA	US7270812B2
OV_5583	Sindbis virus	AR339	RNA	Togaviridae	None	Yes	No	No	NA	Human eosophageal cancer cell line	TTn	NA	NA	NA	NA	NA	Mice xenografted for eosophageal cancer cell line TTn	1.0E+6 pfu	NA	Tumor volume reduced to below 500mm after 32 weeks	Intraperitoneal	Induction of apoptosis by virus infection	NA	NA	US7270812B2