Browse By Model Organism Result Page of OvirusTdb

The total number of records retrieved from this search are 1. Click on ID to see further detail.
IDOV_5429Virus nameVaccinia virusVirus strainLIVP-GFPVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeletion mutant for tk geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismCBA mice sintramuscularly injected for 5.0E+7 RLS-40 cellsIn-vivo virus concentration5.0E+7 pfuIn-vivo toxicityNA In-vivo resultReduction in tumor volume to below 0.2 cubic cm compared to control 0.8 cubic cm after 15 daysMode of deliveryIntratumoralPathway inducedReduction production of IL-6 indicating tumor inhibitionImmunogenic effectNAClinical trialNAPMID27538520