Browse By Model Organism Result Page of OvirusTdb
The total number of records retrieved from this search are 1. Click on ID to see further detail.
IDOV_5429 | Virus nameVaccinia virus | Virus strainLIVP-GFP | Virus genome typeDNA | Virus familyPoxviridae | Virus genome modificationDeletion mutant for tk gene | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismCBA mice sintramuscularly injected for 5.0E+7 RLS-40 cells | In-vivo virus concentration5.0E+7 pfu | In-vivo toxicityNA | In-vivo resultReduction in tumor volume to below 0.2 cubic cm compared to control 0.8 cubic cm after 15 days | Mode of deliveryIntratumoral | Pathway inducedReduction production of IL-6 indicating tumor inhibition | Immunogenic effectNA | Clinical trialNA | PMID27538520 |