The total number of records retrieved from this search are 6. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_711	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	ATCC	NA	NA	NA	NA	NA	NA	NA	C57Bl/6j mice subcutaneously injected with 5.0E+5 B16F10 cells	1.0E+7 PFU to 1.0E+9 PFU for three weeks	NA	77% survived till 30 days (Reduction in tumor volume to 0.15 cubic centimeter compared to control 0.9 cubic centimeter after 15 days)	intravenously	NA	Up-regulation of IL-12, IL-5, IL-10, TNF-alpha	NA	27412241
OV_712	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	ATCC	NA	NA	NA	NA	NA	NA	NA	C57Bl/6j mice subcutaneously injected with 2.0E+5 LLC cells	1.0E+7 PFU to 1.0E+9 PFU for three weeks	NA	80% survived till 40 days (Reduction in tumor volume to 0.3 cubic centimeter compared to control 1.0 cubic centimeter after 20 days)	intravenously	NA	Up-regulation of IFN-gamma	NA	27412241
OV_713	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	ATCC	NA	NA	NA	NA	NA	NA	NA	C57Bl/6j mice subcutaneously injected with 5.0E+5 B16F10 cells (vaccinated with cell-based Reovirus vaccine 8–12 weeks prior to day 0)	1.0E+7 PFU to 1.0E+9 PFU for three weeks	NA	100% survived till 150 days (Reduction in tumor volume to 0.0 cubic centimeter compared to control 1.4 cubic centimeter after 16 days)	intravenously	NA	Up-regulation of IL-12, IL-5, IL-10, TNF-alpha	NA	27412241
OV_714	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	ATCC	NA	NA	NA	NA	NA	NA	NA	C57Bl/6j mice subcutaneously injected with 2.0E+5 LLC cells (vaccinated with cell-based Reovirus vaccine 8–12 weeks prior to day 0)	1.0E+7 PFU to 1.0E+9 PFU for three weeks	NA	100% survived till 200 days (Reduction in tumor volume to 0.0 cubic centimeter compared to control 1.3 cubic centimeter after 11 days)	intravenously	NA	Up-regulation of IFN-gamma	NA	27412241
OV_715	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	ATCC	NA	NA	NA	NA	NA	NA	NA	C57Bl/6j mice subcutaneously injected with 5.0E+5 B16F10 cells (prior single dose of cell-based reovirus vaccine for the treatment of established tumours)	2.0E+7 PFU to 1.0E+9 PFU for three weeks	NA	77% survived till 44 days (Reduction in tumor volume to 0.1 cubic centimeter compared to control 1.2 cubic centimeter after 16 days)	intravenously	NA	Up-regulation of IL-12, IL-5, IL-10, TNF-alpha	NA	27412241
OV_716	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	ATCC	NA	NA	NA	NA	NA	NA	NA	C57Bl/6j mice subcutaneously injected with 2.0E+5 LLC cells (prior single dose of cell-based reovirus vaccine for the treatment of established tumours)	3.0E+7 PFU to 1.0E+9 PFU for three weeks	NA	60% survived till 52 days (Reduction in tumor volume to 0.14 cubic centimeter compared to control 21 cubic centimeter after 15 days)	intravenously	NA	Up-regulation of IFN-gamma	NA	27412241