The total number of records retrieved from this search are 15. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_659	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	100% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_660	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	96% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_661	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	92% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_662	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	92% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_663	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	1 MOI	90% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_664	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	88% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_665	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	94% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_666	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	90% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_667	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	91% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_668	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	1 MOI	88% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_699	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	108% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_700	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	90% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_701	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	100% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_702	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	85% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_703	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	WM1791c	1.0E+5 cells per well	NA	MTT assay	1 MOI	92% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486