The total number of records retrieved from this search are 15. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_669	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	98% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_670	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	78% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_671	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	60% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_672	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	20% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_673	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	1 MOI	12% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_674	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	70% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_675	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	60% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_676	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	17% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_677	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	8% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_678	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	1 MOI	8% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_704	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	110% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_705	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	92% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_706	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	70% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_707	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	25% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_708	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	Yes	No	No	Prof. Richard Marais lab	Human cutaneous melanoma cell line	PMWK	1.0E+5 cells per well	NA	MTT assay	1 MOI	19% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486