The total number of records retrieved from this search are 4. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_741	Adenovirus	AdAFPp-E1A-122	DNA	Adenoviridae	The viral insertion mutant with miR-122 target sequence into AdAFPp-E1A for negatively regulating E1A gene expression	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2 with mimics	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	50 MOI	80% cancer cell viability on day 3	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_743	Adenovirus	AdAFPp-E1A-122	DNA	Adenoviridae	The viral insertion mutant with miR-122 target sequence into AdAFPp-E1A for negatively regulating E1A gene expression	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2 with mimics	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	100 MOI	65% cancer cell viability on day 3	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_745	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2 with mimics	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	50 MOI	61% cancer cell viability on day 3	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_747	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	HepG2 with mimics	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	100 MOI	46% cancer cell viability on day 3	No	No	NA	No response	NA	NA	NA	NA	27450327