The total number of records retrieved from this search are 12. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
IDOV_2169	Virus nameHerpes simplex virus	Virus strainHSV-1-G47-delta	Virus genome typeDNA	Virus familyHerpesviridae	Virus genome modificationMutant for Gamma34.5, ICP6 and alpha47 gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineHongkong university	Origin of cell lineHuman nasopharyngeal carcinoma cell line	Cell lineCNE-2	Concentration of cell line1.0E+5 cells per well	In-vitro toxicityNA	AssayX-gal staining and MTT assay	In-vitro virus concentration0.01 MOI	In-vitro result98% cell survival after day 1	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID22059912
IDOV_2170	Virus nameHerpes simplex virus	Virus strainHSV-1-G47-delta	Virus genome typeDNA	Virus familyHerpesviridae	Virus genome modificationMutant for Gamma34.5, ICP6 and alpha47 gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineHongkong university	Origin of cell lineHuman nasopharyngeal carcinoma cell line	Cell lineCNE-2	Concentration of cell line1.0E+5 cells per well	In-vitro toxicityNA	AssayX-gal staining and MTT assay	In-vitro virus concentration0.01 MOI	In-vitro result90% cell survival after day 2	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID22059912
IDOV_2171	Virus nameHerpes simplex virus	Virus strainHSV-1-G47-delta	Virus genome typeDNA	Virus familyHerpesviridae	Virus genome modificationMutant for Gamma34.5, ICP6 and alpha47 gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineHongkong university	Origin of cell lineHuman nasopharyngeal carcinoma cell line	Cell lineCNE-2	Concentration of cell line1.0E+5 cells per well	In-vitro toxicityNA	AssayX-gal staining and MTT assay	In-vitro virus concentration0.01 MOI	In-vitro result70% cell survival after day 3	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID22059912
IDOV_2172	Virus nameHerpes simplex virus	Virus strainHSV-1-G47-delta	Virus genome typeDNA	Virus familyHerpesviridae	Virus genome modificationMutant for Gamma34.5, ICP6 and alpha47 gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineHongkong university	Origin of cell lineHuman nasopharyngeal carcinoma cell line	Cell lineCNE-2	Concentration of cell line1.0E+5 cells per well	In-vitro toxicityNA	AssayX-gal staining and MTT assay	In-vitro virus concentration0.01 MOI	In-vitro result30% cell survival after day 4	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID22059912
IDOV_2173	Virus nameHerpes simplex virus	Virus strainHSV-1-G47-delta	Virus genome typeDNA	Virus familyHerpesviridae	Virus genome modificationMutant for Gamma34.5, ICP6 and alpha47 gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineHongkong university	Origin of cell lineHuman nasopharyngeal carcinoma cell line	Cell lineCNE-2	Concentration of cell line1.0E+5 cells per well	In-vitro toxicityNA	AssayX-gal staining and MTT assay	In-vitro virus concentration0.01 MOI	In-vitro result10% cell survival after day 5	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID22059912
IDOV_2174	Virus nameHerpes simplex virus	Virus strainHSV-1-G47-delta	Virus genome typeDNA	Virus familyHerpesviridae	Virus genome modificationMutant for Gamma34.5, ICP6 and alpha47 gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineHongkong university	Origin of cell lineHuman nasopharyngeal carcinoma cell line	Cell lineCNE-2	Concentration of cell line1.0E+5 cells per well	In-vitro toxicityNA	AssayX-gal staining and MTT assay	In-vitro virus concentration0.1 MOI	In-vitro result85% cell survival after day 1	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID22059912
IDOV_2175	Virus nameHerpes simplex virus	Virus strainHSV-1-G47-delta	Virus genome typeDNA	Virus familyHerpesviridae	Virus genome modificationMutant for Gamma34.5, ICP6 and alpha47 gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineHongkong university	Origin of cell lineHuman nasopharyngeal carcinoma cell line	Cell lineCNE-2	Concentration of cell line1.0E+5 cells per well	In-vitro toxicityNA	AssayX-gal staining and MTT assay	In-vitro virus concentration0.1 MOI	In-vitro result70% cell survival after day 2	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID22059912
IDOV_2176	Virus nameHerpes simplex virus	Virus strainHSV-1-G47-delta	Virus genome typeDNA	Virus familyHerpesviridae	Virus genome modificationMutant for Gamma34.5, ICP6 and alpha47 gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineHongkong university	Origin of cell lineHuman nasopharyngeal carcinoma cell line	Cell lineCNE-2	Concentration of cell line1.0E+5 cells per well	In-vitro toxicityNA	AssayX-gal staining and MTT assay	In-vitro virus concentration0.1 MOI	In-vitro result30% cell survival after day 3	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID22059912
IDOV_2177	Virus nameHerpes simplex virus	Virus strainHSV-1-G47-delta	Virus genome typeDNA	Virus familyHerpesviridae	Virus genome modificationMutant for Gamma34.5, ICP6 and alpha47 gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineHongkong university	Origin of cell lineHuman nasopharyngeal carcinoma cell line	Cell lineCNE-2	Concentration of cell line1.0E+5 cells per well	In-vitro toxicityNA	AssayX-gal staining and MTT assay	In-vitro virus concentration0.1 MOI	In-vitro result10% cell survival after day 4	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID22059912
IDOV_2178	Virus nameHerpes simplex virus	Virus strainHSV-1-G47-delta	Virus genome typeDNA	Virus familyHerpesviridae	Virus genome modificationMutant for Gamma34.5, ICP6 and alpha47 gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineHongkong university	Origin of cell lineHuman nasopharyngeal carcinoma cell line	Cell lineCNE-2	Concentration of cell line1.0E+5 cells per well	In-vitro toxicityNA	AssayX-gal staining and MTT assay	In-vitro virus concentration0.1 MOI	In-vitro resultAll cells was dead after day 5	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID22059912
IDOV_2209	Virus nameHerpes simplex virus	Virus strainHSV-1-G47-delta	Virus genome typeDNA	Virus familyHerpesviridae	Virus genome modificationMutant for Gamma34.5, ICP6 and alpha47 gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineHongkong university	Origin of cell lineHuman nasopharyngeal carcinoma cell line	Cell lineCNE-2	Concentration of cell lineNA	In-vitro toxicityNA	AssayNA	In-vitro virus concentrationNA	In-vitro resultNA	Model organismBalb/c nude mice xenograft for CNE-2 cell line (1.0E+6 × 10⁶ cells)	In-vivo virus concentration2.0E+7 pfu	In-vivo toxicityNA	In-vivo resultVirus treated mice shows complete regression in tumor and exhibit longer survival time	Mode of deliveryIntratumoral	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID22059912
IDOV_4281	Virus nameAlphavirus	Virus strainM1	Virus genome typeRNA	Virus familyTogaviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineSICB	Origin of cell lineHuman nasopharyngeal carcinoma	Cell lineCNE-2	Concentration of cell line4000 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 pfu	In-vitro result24.5 % cell viability after 72 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedActivation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	Immunogenic effectNA	Clinical trialNA	PMID26373347