Browse By Cell Line Result Page of OvirusTdb

The total number of records retrieved from this search are 8. Click on ID to see further detail.
IDOV_3163Virus nameSemliki forest virusVirus strainSFV-VA7Virus genome typeRNAVirus familyTogaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell line22Rv1Concentration of cell line40000 cells per wellIn-vitro toxicityNAAssayCell proliferation kit 1 assayIn-vitro virus concentration0.01 MOIIn-vitro result100% cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28557974
IDOV_3164Virus nameSemliki forest virusVirus strainSFV-VA7Virus genome typeRNAVirus familyTogaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell line22Rv1Concentration of cell line40000 cells per wellIn-vitro toxicityNAAssayCell proliferation kit 1 assayIn-vitro virus concentration0.1 MOIIn-vitro result100% cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28557974
IDOV_3165Virus nameSemliki forest virusVirus strainSFV-VA7Virus genome typeRNAVirus familyTogaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell line22Rv1Concentration of cell line40000 cells per wellIn-vitro toxicityNAAssayCell proliferation kit 1 assayIn-vitro virus concentration1 MOIIn-vitro result100% cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28557974
IDOV_3166Virus nameSemliki forest virusVirus strainSFV-VA7Virus genome typeRNAVirus familyTogaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell line22Rv1Concentration of cell line40000 cells per wellIn-vitro toxicityNAAssayCell proliferation kit 1 assayIn-vitro virus concentration10 MOIIn-vitro result100% cell deathModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID28557974
IDOV_3738Virus nameVesicular stomatitis virusVirus strainVSV-GPVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationvirus expressing GP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell line22RV1Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBalb/c-rag and gamma negative xenograft for 22Rv1 (2.0E+6)In-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultRegression in tumor volume to 0.4 cm after day 80Mode of deliveryIntratumoralPathway inducedNAImmunogenic effectNAClinical trialNAPMID29696636
IDOV_3739Virus nameVesicular stomatitis virusVirus strainVSV-GPVirus genome typeRNAVirus familyRhabdoviridaeVirus genome modificationvirus expressing GP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate cancer cell lineCell line22RV1Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBalb/c-rag and gamma negative xenograft for 22Rv1 (2.0E+6)In-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultComplete regression in tumor after day 80Mode of deliveryIntravenousPathway inducedNAImmunogenic effectNAClinical trialNAPMID29696636
IDOV_4288Virus nameAlphavirusVirus strainM1Virus genome typeRNAVirus familyTogaviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman prostate carcinomaCell line22Rv1Concentration of cell line4000 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 pfuIn-vitro result39.1 % cell viability after 72 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedActivation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosisImmunogenic effectNAClinical trialNAPMID26373347
IDOV_5067Virus nameAvian orthoreovirusVirus strainARV-PB1Virus genome typeRNAVirus familyReoviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMycobacterium tubeculosis cell lineCell line22RV1Concentration of cell line1.0E+3 cells per wellIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration10 MOIIn-vitro result40% cell viability after 96 hoursModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosisImmunogenic effectInduction of Interferon related gene expressionClinical trialNAPMID28441762